Summer-Newsletter-2026.-v6 - Flipbook - Page 10
Science of Sysmex: Hematology
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CBC – When Every Cell
Counts! Quality Assurance
Concepts Applied to CBC
Testing & BCQM Tool
Features
Presented by: Éric Bonneau, PhD, DEPD,
CSPQ, FCACB Clinical Biochemist
20 Years After ICGHR:
Lessons Learned and the
Path Forward
Presented by: Olga Pozdnyokova, MD,
Director Division of Hematopathology,
Department of Pathology and Laboratory
Medicine Hospital of the University of
Pennsylvania, Philadelphia
Catching Neutrophil
Extracellular Traps (NETs)
in the Act
Presented by: Kandace Gollomp, MD,
Attending Physician, Division of Hematology,
Assistant Professor, Department
of Pediatrics, Children’s Hospital of
Philadelphia, PA
Fragile WBCs
The patient is a 54-year-old female with metastatic breast cancer and new
liver and bone metastasis who is currently undergoing chemotherapy. The
original order on this patient was for a WBC only and no results were obtained
on the XN-SeriesTM analyzer. Repeat testing initiated by the lab showed a
WBC count of 17.03 x 103/µL.
In this sample, the extensive debris in the WNR channel (circled in yellow)
caused the WBC result to be unreliable, so the result was masked (----). If a
differential is part of the order, the XN can acquire the WBC count from the
WDF channel, which is indicated by “&D” next to the WBC parameter. Note
that the “WBC Abn Scattergram” 昀氀ag can be generated by either of these
scattergrams.
Additionally, a “Difference
between WNR and WDF”
action message may be
generated if the total
nucleated cell count from
each of these channels
do not match within the
acceptable limits. The
counts obtained in the
individual scattergrams –
WBC-N (for WNR scatter)
and WBC-D (for WDF
scatter) – can be found on
the “Service” tab in Data
Browser.
Additional 昀氀agging on this
sample includes the “PLT
Clumps?” suspect 昀氀ag. This
昀氀ag can be generated
in the WNR, WDF and
PLT-F (not analyzed on
this sample) channels.
Some of the debris in
the WNR scattergram
is being classi昀椀ed as
platelet clumps as
demonstrated by the
Q-Flags.
NOTE: The individual Q-Flags for each
of the channels can be added to the
customizable Lab Only instructions.
10 | NEWS
PLT Clumps? Q-Flags
CBC + DIFF (Repeat Testing)
